Objective To investigate the effect of abdominal deep breathing exercises on gastrointestinal and psychological symptom clusters in patients with gastroesophageal reflux disease（GERD）. Methods Eighty GERD patients were conveniently selected in a digestive outpatient clinic of a third-level grade-A hospital from July 2017 to February 2018. Patients were randomly divided into the experimental group and the control group with 40 cases in each group. Patients in the experimental group were given conventional drug therapy and routine care plus abdominal deep breathing exercises for 15~20 minutes each time,and twice a day. The control group received conventional drug therapy and routine care. The clinical outcomes including scores of symptom,depression,anxiety,and sleep quality of two groups were evaluated and compared before and 8 weeks after the intervention.Results After intervention,the scores of symptom,anxiety and depression,and Pittsburgh Sleep Quality Index（except hypnotic drug dimension） in two groups were significantly lower. After intervention,the scores of symptoms,anxiety and depression,Pittsburgh Sleep Quality Index（except sleep quality and hypnotic drug dimension） total score and score of each dimension in the experimental group were significantly lower than those in the control group（all P<0.05）.Conclusion Abdominal deep breathing exercises can effectively relieve the gastrointestinal and psychological symptoms of patients with GERD.